Status:
COMPLETED
Efficacy and Safety of Prednisolone and Chloroquine Add on Therapy in Osteoarthritis of the Knee
Lead Sponsor:
Ardabil University of Medical Sciences
Conditions:
Osteoarthritis of the Knee
Eligibility:
All Genders
40-85 years
Phase:
PHASE4
Brief Summary
This study was conducted to evaluate the efficacy and safety of prednisolone and chloroquine add on therapies to combined glucosamine, chondroitin sulfate in osteoarthritis of the knee which will be d...
Detailed Description
Fixed dose glucosamine, chondroitin sulfate combination is a treatment to osteoarthritis with some controversy about efficacy. it seems that addition of other agents may improve efficacy and decrease ...
Eligibility Criteria
Inclusion
- men and non-pregnant women, age 40-85 years with primary OA of at least one knee.
Exclusion
- secondary arthritis related to systemic inflammatory arthritis (including rheumatoid arthritis, psoriatic arthritis, post-infectious arthritis and metabolic arthritis, traumatic arthritis or surgical joint replacement)corticosteroid use:
- oral corticosteroid within the previous 14 days
- intramuscular corticosteroid within 30 days
- intraarticular corticosteroid into the study knee within 90 days
- intra-articular corticosteroid into any other joint within 30 days or
- topical corticosteroid at the site of application within 14 days
- ongoing use of prohibited medication including NSAID, other oral analgesic, muscle relaxant, or low-dose antidepressant for any chronic pain management
- glucosamine or chondroitin within the previous six months
- history of alcohol or drug abuse
- lactation
- concomitant skin disease at the application site
- current application for disability benefits on the basis of knee osteoarthritis; fibromyalgia; other painful or disabling condition affecting the knee
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
230 Patients enrolled
Trial Details
Trial ID
NCT00805519
Start Date
February 1 2009
End Date
April 1 2010
Last Update
April 30 2010
Active Locations (1)
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1
ArdabiUMS Clinic of Rheumatology
Ardabil, Ardabil Province, Iran, 56197