Status:
COMPLETED
Anti-IMP3 Autoantibody and MicroRNA Signature Blood Tests in Finding Metastasis in Patients With Localized or Metastatic Kidney Cancer
Lead Sponsor:
City of Hope Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Kidney Cancer
Eligibility:
All Genders
Brief Summary
This research trial studies the development of a blood test for detecting anti-insulin-like growth factor II mRNA binding protein 3 (anti-IMP3) antibody and micro ribonucleic acid (microRNA) in patien...
Detailed Description
PRIMARY OBJECTIVE: I. To develop a blood test by monitoring the titer of IMP3 autoantibody and/or microRNA (miRNA)/small non-coding RNA (snRNA) expression in patients' serum for the early detection o...
Eligibility Criteria
Inclusion
- Metastatic RCC Patients' Serum Cohort:
- a. Serum samples from patients with metastatic RCC prior to surgical removal of the metastatic and/or primary lesions
- b. Serum samples from patients with localized RCC prior to surgical removal of the lesions
- c. Discarded donors' and patients' discarded/leftover plasma/serum samples from blood bank and other Department of Pathology laboratories
- d. Serum samples from patients with metastatic RCC who had nephrectomies or/and RCC-related biopsies in the referring hospitals
- Metastatic RCC Patients' Tissue Cohort:
- Formalin-fixed paraffin-embedded (FFPE) and/or frozen primary and/or metastatic RCC tissue samples from the corresponding patients serum who are included in inclusion criteria (a-b)
- FFPE and/or frozen benign renal tissue samples which are nearby the tumor and remove during surgical procedures from the corresponding patients who are included in inclusion criteria (a-b)
- Discarded/leftover FFPE and frozen renal tissue samples from Department of Anatomic Pathology and its Tumor Bank
- FFPE primary and/or metastatic RCC tissue samples (unstained slides) from the corresponding patients who are included in inclusion criteria (d)
Exclusion
- Not applicable
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 15 2017
Estimated Enrollment :
155 Patients enrolled
Trial Details
Trial ID
NCT00806650
Start Date
July 1 2008
End Date
November 15 2017
Last Update
December 8 2017
Active Locations (1)
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1
City of Hope Medical Center
Duarte, California, United States, 91010-3000