Status:
UNKNOWN
The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis
Lead Sponsor:
McMaster University
Conditions:
Inflammatory Arthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Inflammatory arthritis is a major cause of permanent joint damage. Joint damage causes functional disability and physical deformity. Many inflammatory arthritis patients develop permanent joint damage...
Detailed Description
The proposed project is a double-blinded randomized-controlled trial to determine if biannual monitoring of inflammatory arthritis disease progression with 1.0T peripheral magnetic resonance imaging (...
Eligibility Criteria
Inclusion
- At least 18 years of age at study enrollment.
- At least three swollen joints; OR,
- Metacarpophalangeal joint(s) positive squeeze test; OR,
- Metatarsophalangeal joint(s) positive squeeze test; OR,
- At least 30 minutes of self-reported morning stiffness.
- At least six weeks of self-reported symptom duration.
Exclusion
- Self-reported symptom onset prior to 17 years of age.
- Medical history of juvenile arthritis
- Evidence of viral arthritis
- A concomitant condition with medical priority over inflammatory arthritis, or that contraindicates treatment with DMARDs excluding sulfa allergy or medically controlled, non-terminal liver disease.
- Refusal to receive DMARD treatment
- Patients with a psychological deficit, or diminished capacity to provide independent, informed consent
- Any contraindication to MRI or x-ray
- Current or planned pregnancy
- Lactation
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2013
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT00808496
Start Date
June 1 2009
End Date
April 1 2013
Last Update
October 7 2011
Active Locations (1)
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1
McMaster University, Division of Rheumatology
Hamilton, Ontario, Canada, L8N 1Y2