Status:
COMPLETED
Role of Mitochondria in Non Severe Asthma
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Asthma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Asthma is a frequent disease characterized by bronchial hyperresponsiveness, inflammation and remodelling. Bronchial remodelling is an abnormal repair process that contributes to the development of po...
Detailed Description
Bronchial remodelling mainly involves an increased mass of bronchial smooth muscle (BSM), which is related with an increase proliferation of BSM cells. Recently, using BSM cells obtained from severe a...
Eligibility Criteria
Inclusion
- Male or female aged more than 18 years
- Diagnosis of intermittent asthma, mild persistent asthma or moderate persistent according to ATS criteria
- Forced expiratory volume in one second \> 60% predicted
- Written informed consent
Exclusion
- Smoker or former smoker (tobacco or cannabis)
- Adults protected by law
- Subjects not affiliated with social security
- Subjects during exclusion relative to another protocol or for which the annual maximum allowance of 3800 euros has been reached
- Subject with any co-morbidity (except chronic rhinitis, chronic sinusitis nasal polyps or gastro-oesophageal reflux)
- Asthma exacerbation within 6 weeks before enrolment
- Infections of the upper airway within 3 months before enrolment
- Chronic viral infections (hepatitis, HIV)
- Pregnancy or breastfeeding
- Contraindications to bronchoscopy
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00808730
Start Date
February 1 2009
End Date
November 1 2009
Last Update
February 17 2010
Active Locations (1)
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1
University Hospital Bordeaux, Hôpital Haut-Lévêque
Pessac, France, 33604