Status:
COMPLETED
Bioavailability and Metabolism of Anthocyanins Following Acute Cranberry Consumption
Lead Sponsor:
Tufts University
Conditions:
Bioavailability
Cardiovascular Disease
Eligibility:
All Genders
21-80 years
Brief Summary
This study hypothesis is that anthocyanins from cranberry juice are bioavailable and can be measured in blood and urine after a single acute consumption of cranberry juice.
Detailed Description
Little is known about the acute or chronic pharmacokinetics and metabolism of anthocyanins consumed in amounts relevant to usual dietary intakes. Thus, we hypothesize that anthocyanins from a single o...
Eligibility Criteria
Inclusion
- Stable CAD Patients
- Men \& postmenopausal women
- Aged 21-80 years
- All Ethnic Groups
- English Language
Exclusion
- Subjects with heart failure are not eligible for participation in this study.
- Women with a positive urine beta HCG pregnancy test and lactating women or women who are planning to become pregnant.
- Clinical history of other major illness including end-stage cancer, renal failure, hepatic failure, gastrointestinal disorders that may impair absorption, or other conditions that in the opinion of the principal investigator make a clinical study inappropriate.
- Regular use of oral steroids
- Cigarette smoking and/or nicotine replacement use
- Regular daily intake of ≥ 2 alcoholic drinks
- Illicit drug use
- History of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study.
- No dietary supplements containing phenolic compounds, i.e., herbal preparations, or berry containing preparations (such as cranberry capsules) for one month prior to study admission.
- Treatment with an investigational new drug within the last 30 days.
Key Trial Info
Start Date :
June 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00809900
Start Date
June 1 2007
End Date
April 1 2008
Last Update
December 2 2009
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111