Status:
COMPLETED
Approach to Predict Steroid Sensitivity in Patients With Asthma
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Asthma
Eligibility:
All Genders
18-55 years
Brief Summary
Inhaled corticosteroids are widely used as the primary therapy for asthma, which affects approximately 20 million people in the United States. While many patients respond to corticosteroid therapy, as...
Eligibility Criteria
Inclusion
- healthy control adult subjects (n=10),
- patients with mild to moderate asthma (n=20) (Table 2, Appendix 4).
- A diagnosis of asthma will be defined as episodic airflow obstruction which is reversible (improvement in FEV1 \>12% when measured via spirometry) after administration of a SABA.
Exclusion
- currently smokers or have been smokers in the past 6 months
- a diagnosis of COPD, bronchiectasis, Allergic Bronchopulmonary Aspergillosis, diagnosis of bacterial, fungal, or viral pneumonia in the past 6 months, or other diagnoses of chronic lung disease.
- subjects being treated with oral systemic corticosteroids for other diseases, those using intranasal steroids in a 2 week period preceding the study, or those requiring an oral corticosteroid burst in the past 6 weeks, or who are receiving treatment with immune modulator medications will also be excluded from the study.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2011
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00811278
Start Date
December 1 2008
End Date
June 1 2011
Last Update
August 26 2021
Active Locations (1)
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1
Truman Medical Center
Kansas City, Missouri, United States, 64108