Status:
COMPLETED
Swiss Intravenous and Intra-arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Collaborating Sponsors:
Swiss Heart Foundation
University of Zurich
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18+ years
Brief Summary
The clinical and radiological data of patients with an acute ischemic stroke treated with intravenous thrombolysis (IVT) or intraarterial thrombolysis (IAT) in a Swiss stroke unit are assessed in a Sw...
Detailed Description
Background: Intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) have been shown to be effective treatments for acute stroke in controlled randomized trials and meta-analyses. However,...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age ≥ 18 years
- Intracranial arterial occlusion confirmed by conventional angiography, MRA or CTA
- National Institute of health Stroke Scale (NIHSS) score ≥ 4 or isolated aphasia or hemianopia
- Time to treatment \< 6 hours
- Exclusion Criteria
- Intracranial haemorrhage on CT scn or MRI
- History of intracranial haemorrhage or subarachnoid haemorrhage
- Platelet count \< 100'000
- International normalized ration (INR) \> 1.5
- Partial thromboplastin time (PTT) \> 1.5 times the normal value
- Known hereditary of acquired haemorrhagic diathesis
- Pre-existing neurological deficit (mRS\>2)
- Previous stroke that might interfere with the neurological assessment (mRS \>2)
- Active gastric ulcer
- Major trauma within the preceding 3 months
- Major surgery within the past 4 weeks
- Childbirth within the previous 4 weeks
- Pregnancy
- Uncontrolled hypertension (\>185/10 on repeated measures despite antihypertensive medication)
- Severe systemic disease with poor prognosis (e.g. cancer, severe heart failure)
- Intracranial neoplasm
- Combined IVT and IAT
- Combined Intravenous and Ultrasound Thrombolysis
Exclusion
Key Trial Info
Start Date :
December 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
1476 Patients enrolled
Trial Details
Trial ID
NCT00811538
Start Date
December 1 2007
End Date
December 1 2015
Last Update
April 13 2016
Active Locations (1)
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1
Dep. of Neurology, Bern University Hospital
Bern, Switzerland, 3010