Status:
COMPLETED
Regional Cortical Cerebral Quantitative MRI Perfusion Correlation Neurocognition in Multiple Sclerosis
Lead Sponsor:
Sunnybrook Health Sciences Centre
Collaborating Sponsors:
Unity Health Toronto
The Physicians' Services Incorporated Foundation
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
16+ years
Brief Summary
Multiple Sclerosis (MS) is a common disease affecting 1/1000 Canadians. Cognition impairment is reported in 40-65% of patients and is socially and functionally disabling. Although multiple sclerosis i...
Detailed Description
We hypothesize that cortical perfusion is a marker of cortical disease severity and correlates with neurocognitive impairment. To show this we will measure regional cortical perfusion and regional bra...
Eligibility Criteria
Inclusion
- established SPMS according to the McDonald criteria
Exclusion
- Patients with a history of drug/alcohol abuse, a premorbid (pre MS) psychiatric history, a head injury with loss of consciousness and a concurrent physical disease requiring medical attention (eg. cardiovascular disease etc), MRI contraindication including implants, pacemaker, aneurysm clips and known renal impairment
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00812474
Start Date
December 1 2008
End Date
November 1 2015
Last Update
November 18 2015
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