Status:
UNKNOWN
Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy
Lead Sponsor:
Mount Sinai Hospital, Canada
Conditions:
Non-arteritic Anterior Ischemic Optic Neuropathy
Eligibility:
All Genders
30+ years
Phase:
PHASE2
Brief Summary
Non-Arteritic Ischemic Optic Neuropathy (NAION) is a disease producing swelling of the optic nerve (the "cable" going from the eye to the brain) resulting in decreased vision. About 15% of patients wi...
Detailed Description
NAION produces an ischemic insult in the optic nerve head presumably due to the hypoperfusion of the short ciliary arteries that supply it. This leads to the release of vascular endothelial growth fac...
Eligibility Criteria
Inclusion
- Patients with newly diagnosed NAION (within the past 30 days but preferably within the first 14).
Exclusion
- Patients who are unable to give informed consent
- Patient with:
- uncontrolled glaucoma
- pregnancy
- lactation
- proliferative diabetic retinopathy
- active clinically significant diabetic macular edema
- active uveitis
- prior treatment with intraocular steroids that incited significant increase in intra-ocular pressure
- other known causes of decreased visual acuity in the recently involved eye such as significant dry or wet macular degeneration
- previous history of other optic neuropathies
- previous history of ocular trauma that resulted in decreased visual acuity
- Patients with baseline amblyopia in the newly involved eye and visual acuity worse than 20/50 prior to the onset of NAION
- Previous treatment for any ocular condition with any investigational drugs
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2012
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00813059
Start Date
February 1 2009
End Date
June 1 2012
Last Update
February 8 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Mount Sinai Hospital, University of Toronto
Toronto, Ontario, Canada, M5G 1X5