Status:
COMPLETED
Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease
Lead Sponsor:
The New York Memory Services
Conditions:
Alzheimer's Disease
Aphasia
Eligibility:
All Genders
50-90 years
Phase:
PHASE2
Brief Summary
The investigators wish to investigate the efficacy of targeted repetitive transcranial magnetic stimulation (rTMS) on expressive language in patients with Alzheimer's disease (AD). In rTMS, magnetic p...
Detailed Description
Subjects for this study will be recruited from Dr. Devi's clinical practice. Eligible subjects must have a diagnosis of possible or probable Alzheimer's disease using NINCDS-ADRDA criteria. The patien...
Eligibility Criteria
Inclusion
- Subjects must have a diagnosis of probable or possible Alzheimer's disease, diagnosed using standardized criteria.
- If subjects are determined by the PI to lack decisional capacity to consent to the study, a legally authorized representative must be available to sign the informed consent on behalf of the subject. In this case the assent of each subject will be obtained as well. If at any time the subject withdraws his or her assent, the subject will be disenrolled from the study.
- Subjects will score at or below 30 on the 60 item naming section of the Boston Diagnostic Aphasia and/or below 50% on the Controlled Word Association (CFL) Category Naming.
Exclusion
- Subjects newly diagnosed with AD and not yet receiving usual care are not eligible.
- Subjects must not have pacemakers.
- They must not have a history of implanted metal objects.
- They must not have a history of seizures or epilepsy.
- There must not be any recent history of migraines.
- There must not be any history of uncontrolled depression.
- They must not be on any medications that will significantly lower the seizure threshold.
- Any other medical condition that is judged by the PI to make rTMS unsafe for the subject.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00814697
Start Date
December 1 2008
End Date
August 1 2012
Last Update
January 28 2014
Active Locations (1)
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1
The NY Memory Services
New York, New York, United States, 10021