Status:
COMPLETED
Nasal Provocation Test With Lysine-Acetylsalicylate (ASA) in Patients With Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Hypersensitivity
Lead Sponsor:
Chulalongkorn University
Conditions:
Aspirin Hypersensitivity
NSAIDs Hypersensitivity
Eligibility:
All Genders
15-70 years
Phase:
NA
Brief Summary
This study aims to compare the efficacy of nasal provocation test with Lysine-Acetylsalicylate in patients with history of NSAIDs hypersensitivity between mucocutaneous symptoms and respiratory sympto...
Eligibility Criteria
Inclusion
- Patients with history of ASA/NSAIDs hypersensitivity with mucocutaneous symptoms and/or respiratory symptoms
Exclusion
- Patients who cannot discontinue drugs before the test as follow
- Nasal corticosteroids/Oral corticosteroids/Leukotriene modifiers for 1 week
- Short-acting antihistamines for 3 days
- Nasal a-mimetics/Oral a-mimetics/Local cromones for 24 hours
- Contraindicated for nasal provocation test: pregnant, exacerbation of allergic rhinitis/asthma, having upper respiratory tract infection within 2 weeks prior to the test, having nose surgery within 8 weeks prior to the test, having severe systemic disease(s)
- Having factors interfere nasal provocation test with Lysine-ASA such as massive nasal polyp, nasal septal perforation, total nasal obstruction at least 1 nostril
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00815126
Start Date
November 1 2008
End Date
April 1 2009
Last Update
November 18 2010
Active Locations (1)
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1
Faculty of Medicine, Chulalongkorn University
Bangkok, Thailand, 10330