Status:
COMPLETED
Prevention of Bleeding in Patient With Cirrhosis Undergoing Dental Extraction
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Conditions:
Liver Cirrhosis
Coagulopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate how effective and cost saving 1-deamino-8-D-arginine vasopressin (desmopressin, DDAVP) is as opposed to the transfusion of blood products in preventing blee...
Detailed Description
Liver cirrhosis is associated with dysregulation of the coagulation system resulting in an increased bleeding tendency in cirrhotic patients. The treatment approach to offset these abnormalities may i...
Eligibility Criteria
Inclusion
- adult patients with biopsy-proven liver cirrhosis or clinical/radiological evidence of cirrhosis, requiring dental extraction
- platelet count of 30,000-50,000/microL and/or INR 2.0-3.0
Exclusion
- the presence of other bleeding disorders besides cirrhosis such as renal dysfunction (creatinine \> 2.0) or HIV
- receipt of blood transfusion within 2 weeks prior to study
- recent acute decompensation of liver cirrhosis
- malignancy excluding hepatocellular carcinoma in the absence of portal vein thrombosis
- treatment with anti-platelet medications (aspirin, non-steroidal anti-inflammatory drugs or clopidogrel) within ten days prior to the extraction
- documented allergy to DDAVP.
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00816127
Start Date
October 1 2003
End Date
May 1 2007
Last Update
January 1 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Mount Sinai School of Medicine
New York, New York, United States, 10029