Status:
TERMINATED
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
Lead Sponsor:
Fraser Health
Conditions:
Septic Shock
Acute Renal Failure
Eligibility:
All Genders
19+ years
Phase:
PHASE4
Brief Summary
The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock pa...
Detailed Description
Septic shock is a significant cause of morbidity and mortality. Early Goal Directed therapy, fluid resuscitation, use of vasopressors and/or inotropes, and appropriate empiric antibiotic administratio...
Eligibility Criteria
Inclusion
- Patients with septic shock according to the Surviving Sepsis Campaign
- Age \> 19
- Most recent eGFR\<40 mls/min
Exclusion
- Pregnant
- Known chronic renal failure patients who are dialysis dependant
- Administration of systemic antibiotics \> 1 dose
- Not expected to survive 28 days due to an underlying medical illness
- Allergy to Piperacillin/Tazobactam or any components of formulation within
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00816790
Start Date
January 1 2009
End Date
June 1 2011
Last Update
September 14 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Royal Columbian Hospital
New Westminster, British Columbia, Canada, V3L 3W7