Status:
TERMINATED
Early Parkinson's Disease (PD) Cross-Sectional
Lead Sponsor:
The University of Texas Health Science Center, Houston
Conditions:
Parkinson's Disease
Eligibility:
All Genders
35-80 years
Brief Summary
Purpose: 1. To see if cytokine levels and oligomeric alpha-synuclein levels in blood and cerebrospinal fluid could be used as biological markers for Parkinson's disease (PD) onset and progression. 2....
Eligibility Criteria
Inclusion
- 35-80 year old men \& women
- Patients with iPD or Parkinsonian syndromes, or controls consisting of healthy subjects, or subjects who have a non-neurodegenerative diagnosis but are otherwise healthy.
- Gives written informed consent
- Pregnant women are not excluded, but will be identified by HCG.
Exclusion
- Parkinsonian symptoms not due to idiopathic (sporadic) PD, such as those that are medication induced, toxic substance induced or representative of an atypical Parkinsonian syndrome will be categorized separately.
- Any unstable or uncontrolled medical or psychiatric condition.
- Renal (creatinine over 1.6) or hepatic insufficiency (LFT three-fold higher than normal range), or a history of significant cardiac disease.
- If there is a history or evidence of coagulopathy, on medications such as Plavix, Aggrenox, heparin, coumadin, or large doses of aspirin, must be able to remain off these medications for at least 3 days, and have stable blood coagulation values prior to any lumbar puncture (LP).
- Significant dementia (MMSE\<25/30 or MOCA\<25/30) that would interfere with study procedures or the giving of informed consent for the study .
- Active infections including skin, respiratory or GI infections, and HIV+ (if undergoing an LP).
- Any evidence of a different neurodegenerative disorder, for example, Alzheimer's Disease or Huntington's Disease.
- fMRI will not be performed is screening questionnaire identifies a reason.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2011
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00817453
Start Date
January 1 2009
End Date
February 1 2011
Last Update
April 14 2011
Active Locations (1)
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1
The University of Texas health Science Center at Houston
Houston, Texas, United States, 77030