Status:
COMPLETED
Tumor Gene Expression in Women With Ovarian Cancer
Lead Sponsor:
University of Chicago
Conditions:
Ovarian Cancer
Eligibility:
FEMALE
18-59 years
Phase:
PHASE4
Brief Summary
The study objective is to compare changes in expression of glucocorticoid-induced genes that may be involved in cell survival signaling in the tumors of ovarian cancer patients before and after an int...
Detailed Description
This trial will examine the upregulation of dexamethasone-inducible genes in the tumors of ovarian cancer patients undergoing surgical debulking. A core biopsy of tumor will be taken at the first oppo...
Eligibility Criteria
Inclusion
- Subject has intraabdominal disease either proven or strongly suspected to be ovarian or primary peritoneal cancer, and will be undergoing surgical debulking.
- Subject is not allergic to dexamethasone, and there is no obvious medical contraindication to dexamethasone.
- Subjects with diabetes requiring drug therapy are excluded.
- Subject is not currently receiving glucocorticoid therapy
- Nasal steroids (e.g. Flonase) are permitted
- Subject understands that this protocol does not have therapeutic intent
- Preoperative serum albumin at least 3.0 mg/dL
- Negative serum or urine pregnancy test in women of childbearing potential
- Signed informed consent
Exclusion
- Males do not get ovarian cancer and therefore will not be included in this trial.
- Patients of all ethnic backgrounds are eligible and will be encouraged to enroll. However we do not expect differences based on ethnicity, and this small study will not therefore be powered to make conclusions about ethnic differences in induction of GR-regulated genes with dexamethasone.
Key Trial Info
Start Date :
January 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00817479
Start Date
January 1 2003
End Date
January 1 2013
Last Update
July 13 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The University of Chicago
Chicago, Illinois, United States, 60637