Status:
TERMINATED
Can Presumptive Anthelminthic Treatment Delay the Progression of HIV in ART-naïve Patients in Rural Africa?
Lead Sponsor:
Swiss Tropical & Public Health Institute
Collaborating Sponsors:
Ifakara Health Research and Development Centre
Insel Gruppe AG, University Hospital Bern
Conditions:
HIV Infections
Helminthiasis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study focuses on one of the major health issues of Sub-Saharan Africa: multi-parasitism and co-infections. In particular this study aims to elucidate the interaction of helminths with HIV. There...
Detailed Description
\* Background: On the basis of immunological considerations and in vitro trials on co-infections there is strong reason to suspect a detrimental effect of helminth infection on the course of HIV. The ...
Eligibility Criteria
Inclusion
- HIV-positive patients
- most recent CD4-count \> 250 c/μl (latest within the previous 7 months)
- anti-retroviral treatment naïve
- age \>18 years
- provide written informed consent
Exclusion
- Pregnant and lactating women in the first week of lactation
- Symptoms of severe anemia (or haemoglobin \<5g/dl within the precious 3 months)
- Symptoms of chronic diarrhea (defined as \>= 3 stools per day of loose consistency for more than 2 weeks)
- Patients on treatment for tuberculosis
- WHO clinical stage 3 disease and CD4-count \<350 c/μl
- WHO clinical stage 4 disease
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
295 Patients enrolled
Trial Details
Trial ID
NCT00817713
Start Date
January 1 2009
End Date
September 1 2010
Last Update
February 16 2011
Active Locations (1)
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1
Chronic Disease Clinic of St. Francis Designated District Hospital
Ifakara, Kilombero, Tanzania, P.O. Box 53