Status:
COMPLETED
The Impact of Grapefruit Juice on the Response to Clopidogrel
Lead Sponsor:
Creighton University
Conditions:
Healthy
Eligibility:
All Genders
19-40 years
Phase:
PHASE4
Brief Summary
This study will measure the percentage of platelet aggregation inhibition with a loading dose of clopidogrel (300 mg) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz of gra...
Detailed Description
This study will examine the effect of GFJ on the loading dose (300 mg) of clopidogrel and will evaluate the effect of GFJ on the maintenance dose (75 mg/day) of clopidogrel. Subjects will be randomize...
Eligibility Criteria
Inclusion
- Ages 19-40
- Health status confirmed by medical history and physical examination and laboratory analysis
Exclusion
- Pregnancy
- Taking routine prescription or over-the-counter prescriptions
- Taken over-the-counter analgesic/anti-inflammatory medication within two weeks of study participation
- Recently had grapefruit juice or regularly drinks grapefruit juice
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00817999
Start Date
November 1 2008
End Date
July 1 2011
Last Update
October 1 2012
Active Locations (1)
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1
Creighton Cardiac Center
Omaha, Nebraska, United States, 68131