Status:
COMPLETED
Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery
Lead Sponsor:
Changhai Hospital
Conditions:
Single Nucleotide Polymorphism
Acute Lung Injury
Eligibility:
All Genders
18+ years
Brief Summary
NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, m...
Eligibility Criteria
Inclusion
- Chinese Han unrelated population
- undergoing elective cardiac surgery with CPB
Exclusion
- malignant tumor
- autoimmune disease, immunodeficiency or immunosuppressive therapy
- chronic renal disease (glomerular filtration rate \< 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification\>A)
- COPD, tuberculosis or other chronic pulmonary diseases
- anemia with hemoglobin lower than 90mmHg
- bleeding disorders
- postoperative pericardial tamponade requiring re-operation
- postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.
Key Trial Info
Start Date :
May 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT00819871
Start Date
May 1 2008
End Date
December 1 2008
Last Update
May 3 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Changhai Hospital, Second Military Medical University
Shanghai, China, 200433