Status:
COMPLETED
MRI Markers of Cartilage Damage in Knee With Osteoarthritis
Lead Sponsor:
American College of Radiology
Collaborating Sponsors:
Pennsylvania Department of Health
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
18+ years
Brief Summary
The objectives of this study are: to identify and develop techniques to minimize precision errors in magnetic resonance imaging (MRI) evaluation of knee cartilage, and to determine if results from new...
Detailed Description
The development of a disease modifying osteoarthritis drugs (DMOADs) is currently limited by the inability to detect and monitor early cartilage damage that would be amenable to treatment. There is gr...
Eligibility Criteria
Inclusion
- Participants must be \>18 years old;
- Participants must have a KL score between 0 and 3;
- Participants must have clearance to use protocol specified equipment: 3T MRI with parallel imaging capability and phased array knee coil (minimum 4 elements);
- Participant had no change of treatment occur within the last 6 months;
- Participants have no plans of changing to a different treatment within the next 3 months;
- Participant must provide a study-specific signed informed consent form.
Exclusion
- Patients with contraindication to 3T MRI: Claustrophobia, Implanted metal or medical device that is not approved for MRI scanning at 3T, pregnancy, inability to tolerate relative immobility for 1 hour;
- Patients with prior knee surgery or trauma of the knee;
- Patients with KL score of 4.
Key Trial Info
Start Date :
November 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00820430
Start Date
November 1 2006
End Date
May 1 2008
Last Update
July 20 2023
Active Locations (5)
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1
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
2
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19017
3
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
4
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111