Status:
COMPLETED
Effects of Oral GLP-1 on Glucose Homeostasis and Appetite Profile in Healthy Male Subjects
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Glucose Homeostasis
Eligibility:
MALE
18-40 years
Phase:
PHASE1
PHASE2
Brief Summary
The investigators aimed to investigate the pharmacokinetic and pharmacodynamic effects of a single dose (2 mg) of oral GLP-1 administered prior to an oral glucose tolerance test (oGTT) in 16 healthy m...
Detailed Description
Background: Glucagon like peptide-1 (GLP-1) promotes satiety and reduces food intake. GLP-1 is secreted from intestinal L-cells into the splanchnic circulation, it is (i) subject to rapid breakdown an...
Eligibility Criteria
Inclusion
- healthy male subjects
- no gastrointestinal or endocrine disorder
Exclusion
- females
- alcohol or drug abuse
- active virus hepatitis
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00822003
Start Date
February 1 2008
End Date
September 1 2008
Last Update
January 14 2009
Active Locations (1)
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1
Clinical Research Center, University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031