Status:
COMPLETED
Study of Repetitive Transcranial Magnetic Stimulation Efficacy on Obsessive Compulsive Disorder (OCD)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Our study's purpose is to show the efficacy of the transcranial magnetic stimulation (a non invasive method of cerebral modulation) in patients suffering from chronic obsessive compulsive disorder (OC...
Detailed Description
Repetitive Transcranial Magnetic Stimulation (rTMS) has been shown to be an effective therapeutic tool for the treatment of several neuropsychiatric disorders including major depression and hallucinat...
Eligibility Criteria
Inclusion
- signed patient informed consent;
- primary obsessive compulsive disorder;
- current YBOCS score at least 15 with or without drug (or obsessive/compulsive subscores of at least 10);
- males/females 18-65yrs;
- treated with at least two adequate dose of SRI at least 8 weeks at some stage of illness;
- currently using adequate, stable dose of SSRI at least 8 weeks but not responding.
Exclusion
- schizophrenia, other psychotic disorders, bipolar I, current major depressive disorder (MADRS\>20), substance/alcohol dependence within last 6 months;
- severe axis II;
- significant suicide risk;
- metallic implant in cranium;
- severe/unstable medical conditions;
- ECT in the last month;
- pregnancy or breastfeeding ;
- history epilepsy; neurological disorder leading to increased intracranial pressure; severe cardiac disorder/intracardiac lines, pacemakers; Gilles de la Tourette syndrome;
- current structured psychotherapy;
- current drug treatment of bipolar disorder.
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00822601
Start Date
November 1 2008
End Date
April 1 2012
Last Update
July 31 2012
Active Locations (1)
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1
Pitie Salpetriere Hospital
Paris, France, 75013