Status:
COMPLETED
Alveolar Macrophage Proteomics in HIV-associated Emphysema
Lead Sponsor:
Philip Diaz
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
HIV
Emphysema
Eligibility:
All Genders
18+ years
Brief Summary
This study is being done to examine lung function changes in individuals with HIV infection and to understand why individuals with HIV have increased risk of lung damage from cigarette smoking.
Detailed Description
To delineate the natural history of HIV associated emphysema in the HAART era. To compare the alveolar macrophage proteomes from HIV-seropositive smokers with emphysema to the alveolar macrophages pro...
Eligibility Criteria
Inclusion
- Clinically stable HIV-seropositive (and HIV-seronegative) individuals
- Ages 18 years and older
- Female subjects on no oral contraception with a negative pregnancy test
- Subjects capable of giving written consent
Exclusion
- Known medical illness that would preclude bronchoscopy/BAL (e.g. unstable angina, new cardiac arrhythmia). This only pertains to subjects involved in the bronchoscopy phase of the study.
- Pregnant females
- Prisoners
Key Trial Info
Start Date :
April 21 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 23 2008
Estimated Enrollment :
365 Patients enrolled
Trial Details
Trial ID
NCT00823927
Start Date
April 21 2006
End Date
June 23 2008
Last Update
November 1 2021
Active Locations (1)
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1
The Ohio State University
Columbus, Ohio, United States, 43026