Status:
COMPLETED
Efficacy and Significance of Antiviral Therapy for Unresectable Hepatitis B Virus-related Primary Liver Cancer
Lead Sponsor:
Eastern Hepatobiliary Surgery Hospital
Conditions:
Primary Liver Cancer
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study is working to research the efficacy and significant of the anti-virus therapy in the unresectable Hepatitis B virus (HBV) related primary liver cancer(PLC) so as to establish treatment stan...
Detailed Description
primary liver cancer(PLC)is one of the world's most common malignancies, especially in East-Asian countries.Hepatitis B virus (HBV) infection is associated with 70-90% of PLC cases in China. PLC can d...
Eligibility Criteria
Inclusion
- Identify patients with PLC in accordance with the clinical diagnostic criteria of PLC.Patients with PLC shall be diagnosed with or without pathology. It is not appropriate to perform liver resection operation.
- serum positive HBsAg≥6 months.
- Criteria of liver function: Child A or B level, serum total bilirubin ≤ 1.5 times the upper limit of normal value, alanine aminotransferase and aspartate aminotransferase ≤ 10 times the upper limit of normal value.
- hemoglobin≥8.5g/dl, PT-INR≤2.3 or PT\>6 seconds of normal value.
- No dysfunction in major organs; Blood routine, kidney function, cardiac function and lung function are basically normal.
- Patients who can understand this trial, male or female, aged 18-70 voluntarily participate in clinical trials and have signed information consent.
Exclusion
- Patients with apparent cardiac, pulmonary, cerebric and renal dysfunction, which may affect the treatment of liver cancer.
- Patients with other diseases which may affect the treatment mentioned here.
- Patients with medical history of other malignant tumors.
- Subjects participating in other clinical trials.
- Women in pregnancy and breast-feeding.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00824707
Start Date
December 1 2008
End Date
December 1 2010
Last Update
April 1 2016
Active Locations (1)
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1
Eastern Hepatobiliary Surgery Hospital
Shanghai, Shanghai Municipality, China, 200438