Status:
COMPLETED
Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control
Lead Sponsor:
Inje University
Conditions:
Pain, Postoperative
Eligibility:
FEMALE
19-65 years
Brief Summary
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors a...
Detailed Description
The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.
Eligibility Criteria
Inclusion
- Patients undergoing total abdominal hysterectomy (TAH) or laparoscopy assisted vaginal hysterectomy (LAVH) under general anesthesia
- Patients who want to use intravenous patient controlled analgesia (PCA) after surgery
- ASA physical status class I, II
Exclusion
- history of drug addiction
- opioid medication within 12 hours before surgery
- previous history of opioid medication for 3 months
- neurologic disorder
- cardiac disorder
- hepatic disease
- renal disease
- respiratory disease such as COPD, asthma
- sleep apnea
- BMI \> 30
- psycotic disorder
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
204 Patients enrolled
Trial Details
Trial ID
NCT00824772
Start Date
September 1 2008
End Date
December 1 2012
Last Update
June 4 2013
Active Locations (1)
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1
Inje University Sanggye Paik Hospital
Seoul, South Korea, 139-707