Status:
UNKNOWN
Dopamine D2 and D3 Receptor Occupancy and Clinical Response in Older Patients With Schizophrenia
Lead Sponsor:
Centre for Addiction and Mental Health
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
This study will provide information regarding dopamine D2/D3 occupancy related with clinical/adverse effects in older people with schizophrenia and schizoaffective disorder. The results of this study ...
Detailed Description
Positron Emission Tomography (PET) studies have demonstrated that a therapeutic window of dopamine D2/3 receptor occupancy (60-80%) is associated with clinical response in younger patients with schizo...
Eligibility Criteria
Inclusion
- Age of 50 and older at time of scanning
- Inpatients or outpatients
- DSM-IV/SCID diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder
- Having NOT been treated with oral antipsychotic treatment for at least 2 weeks or long-acting antipsychotics for at least 6 months (Please note that patients will not be withdrawn from antipsychotic medications for the purpose of meeting inclusion criteria for this study).
Exclusion
- Known history of intolerance or inefficacy to risperidone
- Participation in this study would result in exceeding the annual radiation dose limits (20 mSv) for human subjects participating in research studies.
- Substance abuse or dependence (within past six months)
- Positive urine drug screen
- Positive serum pregnancy test at screening or positive urine pregnancy test before PET scan
- Metal implants or a pace-maker that would preclude the MRI scan
- History of head trauma resulting in loss of consciousness \>30 minutes that required medical attention
- Unstable physical illness or significant neurological disorder including a seizure disorder
- Inappropriate size of head, neck, and body to be able to fit the PET and MRI scans
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00825045
Start Date
December 1 2008
End Date
December 1 2020
Last Update
February 7 2020
Active Locations (1)
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1
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M5T 1R8