Status:
TERMINATED
A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives
Lead Sponsor:
University of Mississippi Medical Center
Conditions:
Obesity
Hypertension
Eligibility:
All Genders
21-100 years
Phase:
NA
Brief Summary
Obesity and hypertension are independent risks for congestive heart failure (CHF) and chronic kidney disease. In obesity induced hypertension, the most common cause of human essential hypertension, th...
Detailed Description
The proposed trial will utilize an open label study design. Patients with hypertension and obesity will be recruited. After a 3-week washout period for patients currently on antihypertensive medicatio...
Eligibility Criteria
Inclusion
- Systolic blood pressure (SBP) between 140 and 160 mmHg and/or a diastolic blood pressure between 90 and 100 mmHg who also have a body mass index \> 30-45.
- Women must be post menopausal
Exclusion
- Women of child bearing potential
- BMI less than 30 or greater than 45
- A creatinine \> 1.8 for females and \> 2.0 for males
- Type 1 or type 2 diabetes
- Current evidence of alcohol or drug abuse problems
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00825188
Start Date
January 1 2009
End Date
March 1 2014
Last Update
May 29 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The University of Mississippi Clinical Research Program
Jackson, Mississippi, United States, 39216