Status:
COMPLETED
Biological Clock Dysfunction in Optic Nerve Hypoplasia
Lead Sponsor:
Yale University
Collaborating Sponsors:
Children's Hospital Los Angeles
Conditions:
Biological Clock Dysfunction
Optic Nerve Hypoplasia
Eligibility:
All Genders
2-10 years
Phase:
EARLY_PHASE1
Brief Summary
Background: Optic Nerve Hypoplasia (ONH) is a leading cause of blindness in children. For unclear reasons, the incidence of ONH is increasing, with ONH affecting about 1 in 10,000 live-born infants. I...
Detailed Description
Objectives and Hypotheses. Our objectives are to define the scope and problems related to biological clock disorders in children with ONH and to develop effective treatments for this condition. Based ...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of ONH (Diagnosis will be confirmed by ocular fundus photography.Disc-macula distance 0.35 or below. In eyes without ONH, the DD/DM ratio is greater than 0.3581.)
- Ages 2-10 years
- Ability to ambulate independently
- Under care of endocrinologist if on pituitary hormone replacement therapy.
Exclusion
- Non-ambulatory
- Active malignancy
- Cardio-respiratory disorder
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2011
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00825591
Start Date
October 1 2008
End Date
September 1 2011
Last Update
September 25 2020
Active Locations (1)
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1
Children's Hospital of Los Angeles
Los Angeles, California, United States, 90027