Status:
COMPLETED
Effect of Smoking, Abstention and Nicotine Replacement Therapy on Wound Healing
Lead Sponsor:
Bispebjerg Hospital
Collaborating Sponsors:
The Danish Medical Research Council
Conditions:
Wound Healing
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The aim was to determine the wound healing capacity in healthy never smokers and smokers who continue to smoke, or quit smoking using transdermal nicotine patch versus placebo patch.
Detailed Description
Two wound healing models were applied: the excisional skin biopsy model to study wound histology and the suction blister model to study epidermal regeneration and skin transudate. In addition blood sa...
Eligibility Criteria
Inclusion
- daily smokers smoking between 15-25 cigarettes per day and never smokers
Exclusion
- chronic medical disease
- atopic dermatitis or other skin disease
- pregnancy
- menopause
- allergy to dressings or patches
- current or recent medication with corticosteroids or NSAID
Key Trial Info
Start Date :
August 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2001
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT00825851
Start Date
August 1 2000
End Date
January 1 2001
Last Update
January 21 2009
Active Locations (1)
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1
Bispebjerg Hospital
Copenhagen, Denmark, 2400