Status:
COMPLETED
Comparing Therapeutic Hypothermia Using External and Internal Cooling for Post-Cardiac Arrest Patients
Lead Sponsor:
Singapore General Hospital
Collaborating Sponsors:
National Heart Centre Singapore
Conditions:
Cardiac Arrest
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Controlled therapeutic hypothermia is a method of preserving neurological function post-resuscitation.It has been associated with improved functional recovery and reduced histological deficits in anim...
Detailed Description
Three randomized clinical studies have been reported showing improved neurological outcome and reduced mortality in post-resuscitation patients treated with hypothermia compared to controls. Of the va...
Eligibility Criteria
Inclusion
- Sustained return of spontaneous circulation (ROSC) after cardiac arrest, for more than 30 min
- Patients aged between 18 to 80 years.
- Patients who are hemodynamically stable, with a systolic BP \> 90 mmHg with or without inotropic support.
- Patients comatose or unresponsive post-resuscitation
Exclusion
- Hypotension despite fluid and/or vasopressor support
- Positive pregnancy test in women below 50 years
- Premorbid status bedbound and uncommunicative
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00827957
Start Date
October 1 2008
End Date
October 1 2014
Last Update
February 10 2017
Active Locations (2)
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1
National Heart Centre Singapore
Singapore, Singapore, 168752
2
Singapore General Hospital
Singapore, Singapore, 169608