Status:
COMPLETED
Beta-blockade Effects on Memory for Cocaine Craving
Lead Sponsor:
Medical University of South Carolina
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Dependence
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.
Detailed Description
This study will employ cocaine-dependent individuals to investigate the acute effects of propranolol vs. placebo, administered immediately after a retrieval session of cocaine cue exposure, on the sub...
Eligibility Criteria
Inclusion
- Current cocaine dependence (within past month)
- Able to provide informed consent
- Use of birth control by female participants (barrier methods, surgical sterilization, IUD, or abstinence)
- Live within 50-mile radius of research site
- Consent to remain abstinent from all drugs of abuse (except nicotine) for 24 hours prior to inpatient admission and follow-up assessment
- Consent to random assignment to propranolol or placebo
Exclusion
- Women who are pregnant, nursing or are of childbearing potential and not practicing/using birth control
- Evidence or history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal or neurological disease
- Significant liver impairment
- History of or current psychotic disorder, current severe major depressive disorder, bipolar affective disorder or a severe anxiety disorder
- Currently taking anti-arrhythmic agents, psychostimulants or other agents known to interfere with heart rate and skin conductance monitoring
- Known or suspected hypersensitivity to propranolol
- Individuals taking medications that could adversely interact with the study medication, including, but not limited to albuterol, insulin, or significant inhibitors of CYP2D6
- Individuals with bronchial asthma or chronic obstructive pulmonary disease
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00830362
Start Date
February 1 2009
End Date
July 1 2011
Last Update
November 30 2012
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425