Status:
TERMINATED
The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
AZ-VUB
Conditions:
Minor Intra-uterine Abnormalities
Eligibility:
FEMALE
Up to 36 years
Phase:
PHASE2
Brief Summary
This is a comparative, controlled trial to evaluate the impact of treating undetected, asymptomatic, predefined minor uterine cavity abnormalities on the success of IVF treatment.
Detailed Description
Introduction- Implantation failure after IVF may be due to endometrial function, embryo quality or a combination of both. The prevalence of minor intracavitary pathology in cases with an apparent norm...
Eligibility Criteria
Inclusion
- Normal Transvaginal Ultrasound
- No prior hysteroscopy
- Regular menstrual cycle
- Single embryo transfer
- BMI between 18 and 29
- Presence of both ovaries
- Primary or secondary infertility
- Women indicated for a first IVF/ICSI cycle
Exclusion
- Recurrent miscarriage
- Prior hysteroscopic treatments
- Endometriosis \> AFS Stage II
- Meno-metrorrhagia (defined as any intermenstrual loss of blood)
- Submucosal/Intracavitary Fibroids taking more than 50% of the cavity
- Hydrosalpinx
- FSH/LH \> 12IU/L on day 3
- Polyps taking more than 50% of the cavity
- Severe adhesions \> grade II
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT00830401
Start Date
June 1 2007
End Date
March 1 2009
Last Update
June 4 2015
Active Locations (1)
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1
UMC Utrecht
Utrecht, Utrecht, Netherlands, 3500VW