Status:
TERMINATED
Does Transcranial Magnetic Stimulation of the Cingulate Cortex Modulate the Perception of Dyspnoea?
Lead Sponsor:
University of Oxford
Conditions:
Malignancy
Eligibility:
All Genders
18+ years
Brief Summary
The treatment we are studying is Transcranial Magnetic Stimulation (TMS). In TMS, an electromagnetic pulse is passed into the brain through a coil placed on the head. Previous studies have shown TMS t...
Detailed Description
This protocol describes an exploratory crossover pilot study to assess whether targeted repetitive pulse Transcranial Magnetic Stimulation (TMS) i.e. targeted at the anterior cingulate cortex (ACC), a...
Eligibility Criteria
Inclusion
- Refractory dyspnoea (persisting sensation of air hunger despite optimisation of medical treatment)
- Histocytologically proven thoracic malignancy
- Written informed consent
Exclusion
- Age \<18 years
- Left-handed
- Structural brain disease (including cerebral metastasis)
- Personal or family history of seizures
- Implantable metallic objects e.g. a pacemaker, or other contraindication to transcranial magnetic stimulation
- Pregnant or breast feeding
- Previous electroconvulsive therapy (ECT)
- Poor mobility
- Visual impairment
- Lack of social support / home to go to after the study treatment
- Alcohol dependency
- PaCO2 \>6kPa at rest
- Inability to provide informed consent
Key Trial Info
Start Date :
February 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00830921
Start Date
February 1 2008
End Date
January 1 2012
Last Update
June 18 2012
Active Locations (1)
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1
Oxford Centre for Respiratory Medicine
Oxford, United Kingdom, OX3 7LJ