Status:
TERMINATED
Haloperidol vs Olanzapine for the Management of ICU Delirium
Lead Sponsor:
Richard Hall
Collaborating Sponsors:
Dalhousie University
Conditions:
Delirium
Agitation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this randomized clinical trial is to determine whether haloperidol is superior to olanzapine for the treatment of ICU acquired delirium. The hypothesis is that haloperidol is in fact su...
Detailed Description
Delirium is defined as a disturbance of consciousness characterized by an acute onset of impaired cognitive function. Although delirium is thought to be common in the Intensive Care Unit (ICU) there a...
Eligibility Criteria
Inclusion
- All patients who are 18 years or older who are admitted for more than 24 hours to the ICU.
- Patients screened for delirium using the ICDSC with a score greater than or equal to 4 or with clinical manifestations of delirium.
Exclusion
- Patients unlikely to survive 24 hours.
- Patients with a primary neurologic reason (i.e. stroke, dementia-related psychosis) for ICU admission.
- Patients with QTc interval greater than 440 msec.
- Pregnant patients.
- Patients who are breast feeding.
- Patients in whom haloperidol, or olanzapine is contraindicated.
- Patients allergic to haloperidol, olanzapine, quetiapine, risperidone, loxapine or methotrimeprazine.
- Patients who do not have a urinary catheter.
- Patients who have received haloperidol, olanzapine, quetiapine, risperidone, loxapine or methotrimeprazine within 14 days.
- Patients unable to undergo assessment (i.e. patients with developmental disability or mental incapacity prior to ICU admission).
- Prolonged (greather than 24 hours) comatose patients who have a defined structural reason for their decreased level of consciousness.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2011
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00833300
Start Date
June 1 2008
End Date
November 1 2011
Last Update
August 3 2012
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Halifax Infirmary; Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada
2
Victoria General Hospital; Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada