Status:
COMPLETED
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Orthostatic Hypotension
Spinal Cord Injury
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how ...
Detailed Description
Blood pressure regulation is compromised in persons with tetraplegia due to de-centralization of sympathetic cardiovascular control, associated with hypotension during upright positioning (7, 10, 18, ...
Eligibility Criteria
Inclusion
- Spinal Cord Injured Subjects:
- chronic spinal cord injury (1 year post injury) with a seated MAP of 65mmHg (almost all individuals with tetraplegia demonstrate this)
- Male or female with an age of 18 - 65 years
- Control Subjects:
- Male or female with an age of 18 - 65 years
Exclusion
- Spinal Cord Injured Subjects:
- acute illness
- cardiovascular disease
- renal disease
- medications that affect the cardiovascular system
- Control Subjects:
- acute illness
- cardiovascular disease
- renal disease
- medications that affect the cardiovascular system
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00835224
Start Date
May 1 2010
End Date
August 1 2013
Last Update
April 23 2014
Active Locations (1)
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1
VA Medical Center, Bronx
The Bronx, New York, United States, 10468