Status:
COMPLETED
Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia
Lead Sponsor:
Peking University
Conditions:
Oral Epithelial Dysplasia, Mild or Moderate Grade
Eligibility:
All Genders
Brief Summary
Oral epithelial dysplasia (OED) is one of the common precancerous lesions among Chinese adults. Biomarker is not available for detection of malignant potential of OED till now. p16 is an important tum...
Detailed Description
* Background: Identification of malignant potential of oral epithelial dysplasia (OED) is virtually impossible on histopathological grounds alone. Inactivation of p16 gene by CpG methylation is an ear...
Eligibility Criteria
Inclusion
- histological diagnosis of mild or moderate grade OED; and
- enough amount of tissue sample from OED lesion for genomic DNA extraction; and
- available of methylation status of p16 CpG island in the extracted DNA sample.
Exclusion
- histological diagnosis of severe grade OED or malignant disease; or
- amount of tissue sample is not enough for preparation of genomic DNA (20ng); or
- quality of the prepared DNA is not good enough for detection of p16 methylation; or
- OED treatment history by LASER, radiotherapy, or chemotherapy
Key Trial Info
Start Date :
March 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2008
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT00835341
Start Date
March 1 2005
End Date
October 1 2008
Last Update
June 1 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Oral Medicine, Peking University School and Hospital of Stomatology
Beijing, China, 100081