Status:
UNKNOWN
Cognitive Behavioural Analysis System of Psychotherapy (CBASp) Versus Escitalopram in Chronic Depression
Lead Sponsor:
University Hospital Freiburg
Collaborating Sponsors:
University Hospital, Bonn
Conditions:
Chronic Depression
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
60 patients with chronic major depressive disorder according to DSM-IV will be included into the study. Patients will be randomized to receive an open treatment either with CBASP, a psychotherapy for ...
Detailed Description
The psychotherapeutic treatment with CBASP will be conducted in 2 weekly sessions for the first 4 weeks, one per week thereafter until week 9, followed by one session every 2 weeks for 20 more weeks. ...
Eligibility Criteria
Inclusion
- Chronic MDD according to DSM-IV (modification: depressive symptomatology for at least one year), or recurrent MDE (third or greater episode with the immediately preceding episode being no more than 2.5 years before the onset of the present episode)
- Age 18-65
- Score of at least 18 on the Montgomery-Asberg-Rating Scale for Depression (MADRS)
Exclusion
- Acute risk for suicide
- History of psychotic symptoms, bipolar disorder or dementia
- Severe substance-related abuse or dependence disorder
- Schizotypal, antisocial or borderline personality disorder
- Serious medical condition
- Severe cognitive impairment
- Absence of a response to previous adequate trial of the study medication/CBASP
- Hypersensitivity to Escitalopram
- Treatment with a MAO-inhibitor within 1 week before the initiation of study treatment
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00837564
Start Date
February 1 2009
End Date
April 1 2011
Last Update
June 30 2010
Active Locations (2)
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1
University of Bonn, Dept. of Psychiatry
Bonn, Germany, D-53105
2
University of Freiburg, Dept. of Psychiatry and Psychotherapy
Freiburg im Breisgau, Germany, D-79104