Status:
COMPLETED
Genetic Determinants of Response to Beta Blockade
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Research Resources (NCRR)
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The overall goal of this project is to determine the genetic factors contributing to interindividual differences in response to beta-blockade.
Detailed Description
The Aim is to define the contribution of genetic variation to the interindividual variability in response to β-blockade. The rationale for the study is as follows: Beta-blockers prevent the activation...
Eligibility Criteria
Inclusion
- Subject must be willing to give written informed consent and be able to adhere to diet and study schedules.
- Subjects must be free of any clinically significant disease that requires a physician's care and/or would interfere with the study evaluations.
- Subjects must have a clinically acceptable physical examination and ECG.
- Laboratory tests (CBC, blood chemistries, and urinalysis) must be within clinically acceptable limits.
Exclusion
- Any subject who has taken any prescription or over-the-counter drugs, other than oral contraception if female, within one week prior to study drug administration.
- Subjects who are presently, or were formerly, narcotic addicts or alcoholics.
- Active smokers.
- Subjects who have a clinically significant allergy/intolerance to atenolol.
- Females with a positive serum/urine pregnancy test at screening.
- Females who are nursing.
- Subjects with complete heart block/ any other significant cardiovascular disease.
- Subjects with a history of asthma symptoms or medication for it within last 10 years.
- Subjects who have a systolic blood pressure \< 90 mm Hg or diastolic blood pressure \< 50 mm Hg or heart rate \< 50/min at the screening visit or on the baseline pre drug values on the study day.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2014
Estimated Enrollment :
154 Patients enrolled
Trial Details
Trial ID
NCT00837902
Start Date
January 1 2009
End Date
December 31 2014
Last Update
November 30 2018
Active Locations (1)
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1
Vanderbilt University
Nashville, Tennessee, United States, 37203