Status:
COMPLETED
Effect of Glutamine on Intestinal Permeability in Crohn's Disease
Lead Sponsor:
All India Institute of Medical Sciences
Conditions:
Crohn's Disease
Eligibility:
All Genders
15-60 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to see whether enteral glutamine supplementation improves intestinal permeability and small intestinal morphology in patients with Crohn's disease.
Detailed Description
Glutamine is the most abundant amino acid in the body constituting 50% to 60% of total free amino acid pool in muscle and 20% in plasma. Recently it has been reclassified as a conditionally essential ...
Eligibility Criteria
Inclusion
- All the consecutive patients with Crohn's disease in the remission phase with an abnormal intestinal permeability (IP)
Exclusion
- Patients in the active phase of the disease i.e. CDAI score \>150
- Patients with a normal intestinal permeability i.e. LMR \< 0.0373
- Patients already taking a high protein nutritional supplement
- Patients with other associated systemic diseases like chronic liver disease, chronic kidney disease, diabetes mellitus, malignancy
- Patients with a special physiologic condition i.e., pregnancy or lactation.
- Patients lesser than 15 years (pediatric group) and more than 60 years of age (elderly patients)
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00838149
Start Date
November 1 2005
End Date
November 1 2008
Last Update
February 6 2009
Active Locations (1)
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1
All India Institute of Medical Sciences
New Delhi, New Delhi, India, 110029