Status:
COMPLETED
Variability in Adrenergic Response
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Research Resources (NCRR)
Conditions:
Vascular Reaction to Medications
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The goal of this project is to determine the genetic factors contributing to interindividual differences in response to physiological and pharmacological vasoconstrictors and vasodilators.
Detailed Description
The dorsal hand vein model is a relatively non-invasive and robust experimental model to examine the local in vivo effect of vasoactive drugs without elucidating systemic counterregulatory reflexes. I...
Eligibility Criteria
Inclusion
- Age between 18 and 40 years, inclusive.
- Subject must be willing to give written informed consent and be able to adhere to diet and study schedules.
- Subjects must be free of any clinically significant disease that requires a physician's care and/or would interfere with the study evaluations.
- Subjects must have a normal or clinically acceptable physical examination and ECG.
- Clinical laboratory tests (CBC, blood chemistries, and urinalysis) must be within normal limits or clinically acceptable to the investigator.
Exclusion
- Any subject who has taken any prescription or over-the-counter drugs, other than oral contraception if female, within two weeks prior to study drug administration.
- Subjects who are presently, or were formerly, narcotic addicts or alcoholics.
- Subjects who have a clinically significant allergy/intolerance to phenylephrine.
- Females with a positive serum/urine pregnancy test at screening.
- Females who are nursing.
- Subject using sildenafil or other phosphodiesterase inhibitors.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT00838695
Start Date
January 1 2009
End Date
December 1 2011
Last Update
October 26 2018
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232