Status:
COMPLETED
Effect Of Obesity On Ozone-Induced Airway Inflammation
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
National Institute of Environmental Health Sciences (NIEHS)
Environmental Protection Agency (EPA)
Conditions:
Obesity
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the effect of ozone exposure on airway reactivity and inflammation in obese vs. non-obese adults.
Detailed Description
Obesity has been shown to be associated with initial onset of asthma in children and increased airway hyperresponsiveness in adults (1,2). An important aspect of these epidemiologic data is that the i...
Eligibility Criteria
Inclusion
- Twenty (20) non-obese, non-overweight (body mass index, 18 kg/m2 \> BMI \< 25 kg/m2, waist circumference \< 35 inches) subjects and 20 obese (30 kg/m2 \> BMI \< 38 kg/m2, waist circumference \>= 35 inches) volunteer females between 18-35 yrs of age
Exclusion
- Are female and pregnant or have any reason to believe you might be pregnant.
- Are not between 18 and 35 years old.
- Have a history of asthma or have current hay fever.
- Have ever smoked more than 10 cigarettes (one half pack) a month or smoked during the past 30 days.
- Have a history of acute or chronic cardiovascular disease, chronic respiratory disease, and acute respiratory illness within 4 weeks.
- Have contraindications for performing sustained light exercise.
- You've been in a recent or recurring exposure to a dusty environment at work
- If you are unwilling to refrain from strenuous physical activity for 24 hours before and after each exposure.
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00839943
Start Date
May 1 2006
End Date
February 1 2012
Last Update
August 27 2012
Active Locations (1)
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1
US EPA Human Studies Facility-UNC -CH campus
Chapel Hill, North Carolina, United States, 27599