Status:
COMPLETED
Is Carotid Intima-media Thickness Affected by A1C Variability?
Lead Sponsor:
Yonsei University
Conditions:
Type 2 Diabetes
A1C Variability
Eligibility:
All Genders
34-79 years
Brief Summary
This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.
Eligibility Criteria
Inclusion
- type II
- fluoroscopy in carotid once a year during 2 years
Exclusion
- type 1 diabetes
- history or clinical evidence of coronary artery disease or cerebral or peripheral vascular disease
- the presence of albuminuria (defined as 24 hour urine albumin excretion ≥ 30 mg)
- renal dysfunction (defined as creatinine blood level ≥ 2.0 mg/dL)
- hepatic dysfunction (defined as alanine aminotransferase and/or aspartate aminotransferase blood level ≥ 3 × upper normal limit)
- smoking within the past 3 months prior to commencement of the study
- use of any medication likely to alter IMT such as calcium channel blocker, thiazolidinedione, antiplatelet agent (clopidogrel, cilostazol)
- use of glucocorticoid
- pregnancy
- severe concomitant disease such as cancer
- infection
- Cushing's syndrome
- acromegaly, or any other disorder likely to alter glycemia
- primary hypercholesterolemia
- hypothyroidism or hyperthyroidism
- use of any hormonal drugs
- alcoholism or drug abuse
Key Trial Info
Start Date :
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00842972
Last Update
September 15 2009
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