Status:
COMPLETED
Spinal Abnormalities in Neurofibromatosis Type 1 (NF1)
Lead Sponsor:
University of Utah
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Neurofibromatosis Type 1
Eligibility:
All Genders
6-9 years
Brief Summary
The purpose of this study is to determine the incidence and clinical history of neurofibromatosis type 1-related spinal abnormalities.
Detailed Description
Neurofibromatosis type 1 (NF1) is a common genetic disorder that is associated with spinal abnormalities which are varied and may include scoliosis, neurofibromas, meningoceles, and vertebral defects....
Eligibility Criteria
Inclusion
- Diagnosis of NF1
- Age greater than 6 years at time of enrollment
- Age less than 9 year and 1 day at time of enrollment
- Tanner Stage not greater than 1
Exclusion
- Prior surgical repair of spine
- Short-segment (4-6 vertebrae) curve with a Cobb angle of 45°or more
- Hormone replacement therapy
- Chronic steroid use
- Tibial pseudarthrosis
- Other chronic medical problems known to influence bone health (i.e. diabetes mellitus, cerebral palsy, etc.)
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT00844129
Start Date
December 1 2006
End Date
December 1 2012
Last Update
May 3 2018
Active Locations (1)
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1
University Health Care, 50 North Medical Drive
Salt Lake City, Utah, United States, 84132