Status:
COMPLETED
Cue Induced Imaging in Nicotine Dependent Smokers
Lead Sponsor:
Medical University of South Carolina
Conditions:
Nicotine Dependence
Eligibility:
All Genders
18-60 years
Brief Summary
The purpose of this study is to evaluate the relationship between craving to smoke and areas activated in brain. The researchers are using functional magnetic resonance imaging (MRI) that measures bra...
Detailed Description
Functional magnetic resonance imaging has demonstrated that the same types of environmental cues that induce craving activate an integrated network of brain areas involved in the appetitive and motiva...
Eligibility Criteria
Inclusion
- Inclusion Criteria (nicotine dependent smoking group):
- Age 18 - 60.
- Participants will meet criteria for primary nicotine dependence, smoke at least 70% of days in the last 30 days prior to assessment.
- Able to read and understand questionnaires and informed consent.
- Right-handed.
- Currently is not engaged in, and does not want, treatment for nicotine related problems.
- Able to maintain abstinence from nicotine during the study period.
- Participants must have a negative rapid-screening UDS and pregnancy test prior to imaging session.
- Inclusion Criteria (nonsmoking control group):
- Age 18 - 60.
- Does not meet the DSM-IV criterion for lifetime or current substance dependence.
- Has used tobacco products no more than on experimental basis (none in past year).
- Participants must have a negative rapid-screening UDS and pregnancy test prior to session.
- Righthanded.
- Exclusion Criteria (all participants):
- Currently meets DSM-IV criteria for any other psychoactive substance dependence disorder except nicotine dependence.
- Any psychoactive substance abuse within the last 30 days as evidenced by subject report or urine drug screen.
- Meets DSM-IV criteria for current axis I disorders of major depression, panic disorder, obsessive compulsive disorder, post-traumatic stress syndrome, bipolar affective disorder, schizophrenia, or any other psychotic disorder or organic mental disorder. The rationale for excluding them is that symptoms from these disorders may affect dependent variables and complicate interpretation of the data.
- Has current suicidal ideation with plan or homicidal ideation.
- Need for maintenance or acute treatment with any psychoactive medication including antiseizure medications.
- Clinically significant medical problems such as cardiovascular, renal, GI, or endocrine problem that would impair participation or limit ability to participate in scan.
- Sexually active females of child-bearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control.
- Has current charges pending for a violent crime (not including DUI related offenses).
- Persons with ferrous metal implants or pacemaker since fMRI will be used.
Exclusion
Key Trial Info
Start Date :
February 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00844701
Start Date
February 1 2008
End Date
December 1 2009
Last Update
November 1 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425