Status:
COMPLETED
Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes
Lead Sponsor:
In-Young Choi, Ph.D.
Conditions:
Type 2 Diabetes
Oxidative Stress
Eligibility:
All Genders
30-55 years
Phase:
NA
Brief Summary
Oxidative stress has been implicated in the development and complications of diabetes. Hyperglycemia and insulin resistance or insufficiency in diabetes can cause oxidative stress by excessive reactiv...
Detailed Description
The brain contains measurable amounts of glutathione that contribute to the antioxidant pool in the brain and guards against disease processes that are caused by oxidative stress. Since the brain is t...
Eligibility Criteria
Inclusion
- 30-55 years of age
- Diabetic being treated with diet and any of the following: insulin, or other diabetic specific drug such as metformin, sulfonylurea or sitagliptin.
- Healthy subjects age and gender matched to diabetes patient
Exclusion
- Use of any anti-inflammatory or antioxidant medications other than small daily doses of Aspirin (ASA:325 mg) and a daily multivitamin
- Co-existing chronic inflammatory conditions such as Crohn's disease, rheumatoid arthritis, chronic or acute infections
- Any concurrent neurological disease except for mild diabetic autonomic or peripheral neuropathy
- Postmeal C peptide \> 0.3 mg/dl
- Normal healthy subjects who have any abnormal inflammatory marker, hyperlipidemia, or concurrent disease
- Diseases associated with abnormal glutathione metabolism
- Elevated serum creatinine levels, abnormal complete blood count (CBC), abnormal liver function tests or elevated serum homocysteine
- Morbid obesity
- History of hypoglycemic unawareness
- Pregnant women and women who are breastfeeding
- Patients with poor venous access
- Smokers
- Subject who consumes an excess of alcohol or abuses drugs
- History or or presence of bleeding disorder or use of anticoagulant drug
- History of oxalate renal calculi
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00845130
Start Date
September 1 2009
End Date
December 1 2014
Last Update
May 3 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160