Status:
COMPLETED
Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery
Lead Sponsor:
University Hospital Birmingham
Collaborating Sponsors:
University of Birmingham
Brighton and Sussex University Hospitals NHS Trust
Conditions:
Myocardial Reperfusion Injury
Cardiac Output, Low
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Open-heart surgery causes injury of the heart muscle. Although this is usually mild, temporary and reversible, if it is severe it can endanger life and require additional high cost care. During surger...
Eligibility Criteria
Inclusion
- Adult
- First-time
- Isolated coronary artery bypass surgery
Exclusion
- Diabetes Mellitus
- Renal impairment with Creatinine greater than or equal to 200micromol/L
- Atrial fibrillation
- Amiodarone therapy, recent (in last month) or current
- Hepatic impairment, significant preoperative
- Peripheral neuropathy
- Pregnancy or breast-feeding
- Emergency surgery or required on clinical grounds within 5 days of referral
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
290 Patients enrolled
Trial Details
Trial ID
NCT00845364
Start Date
February 1 2007
End Date
April 1 2010
Last Update
May 20 2010
Active Locations (2)
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1
University Hospital Birmingham
Birmingham, West Midlands, United Kingdom, B15 2TH
2
Brighton & Sussex University Hospitals NHS Trust
Brighton, West Sussex, United Kingdom, BN2 5BE