Status:
COMPLETED
Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine
Lead Sponsor:
Clinvest
Collaborating Sponsors:
Endo Pharmaceuticals
Conditions:
Migraine
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Subjects enrolled at 2 investigative sites will complete 3 visits. Following Visit 1, during a 1-month Baseline Period, subjects will treat with their usual medication and document any warning signs (...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA
- Subject has at least a one-year history of migraine with or without aura meeting International Headache Society criteria (see Appendix)
- Subject has a 3-month history of averaging 3-6 migraines per month
- Subject reports premonitory symptoms and the ability to predict at least 50% of high impact headaches
- Subjects must currently or have in the past successfully utilized a triptan as an acute treatment for migraine as determined by the investigator.
- Male or female at least 18 years of age
- Subject of childbearing potential agrees to use adequate contraception during the study. Adequate methods of contraception are to be determined by the investigator and should be consistent with contraceptive care administered in the regular clinical use of frovatriptan and topiramate.
- Subject is aware of prodrome symptoms that may include physiological, psychological or cognitive changes. These may include, but are not limited to such symptoms as Pre-Menstrual Syndrome (PMS), change in mood, energy level, appetite, food craving, nausea, sense of hearing, sense of smell or swelling/fluid retention, excessive yawning, head pain, muscle pain/tenderness, irritability, confusion, extreme sleepiness, impaired speech or impaired memory. (The subject should be able to differentiate these symptoms from other similar symptoms that do not precede migraine). The symptoms should precede migraine by 4-24 hours signaling an impending migraine attack.
- Subject is able to understand instructions for the study and complete the diary
- Subject is willing to give informed consent to participate in the study
- Any migraine prophylactic medication must have a stabilized dosage for one month
- EXCLUSION CRITERIA
- History of any medical condition that would confound the results of the study including but not limited to the following:
- Hepatic disease or significant hepatic dysfunction
- History of pancreatitis
- History of thrombocytopenia
- History of glaucoma
- History of osteoporosis or osteopenia
- Cardiovascular Disease - Coronary artery disease, Ischemic heart disease or Significant Arrhythmia
- History of active Cerebrovascular Disease
- Hypertension - Uncontrolled hypertension in a non-migrainous state (\> 160 mmHg systolic or \>95 mmHg. diastolic). Hypertension must be controlled effectively with medication for a period of 3 months.
- Basilar or Hemiplegic Migraine
- Significant peripheral vascular disease or Raynaud's Syndrome
- Significant Active Renal, Hepatic, Gastrointestinal, Endocrine or
- Neurological Disease
- History of depression, mood problems or suicidal thoughts or behavior that in the opinion of the Investigator would interfere with participation in the study.
- History of ergotamine, "triptan", or analgesic abuse within past 3 months
- History of current or recent drug or alcohol abuse that would interfere with participation in the study.
- More than 15 headache days per month within past 3 months.
- Women who are pregnant or breast feeding
- Subjects with known hypersensitivity or intolerance to topiramate or any triptan-like medication
- Subject is scheduled for surgical procedure to occur while enrolled in study.that in opinion of the Investigator would interfere with participation in the study.
- Subject is on a ketogenic diet
- Participation in another investigative drug study within the previous 30 days
- Excluded medications: MAO Inhibitors, lithium, methylergonovine, methysergide, ergotamine-containing products, or topiramate daily for migraine prophylaxis.
Exclusion
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT00846495
Start Date
August 1 2009
End Date
January 1 2011
Last Update
January 13 2012
Active Locations (2)
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1
Physician Associates LLC
Oviedo, Florida, United States, 32765
2
Clinvest
Springfield, Missouri, United States, 65807