Status:
WITHDRAWN
Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance
Lead Sponsor:
Tulane University Health Sciences Center
Conditions:
Insulin Resistance
Endothelial Dysfunction
Eligibility:
All Genders
45-85 years
Phase:
PHASE1
PHASE2
Brief Summary
The hypothesis is that GHRP-3 will exert beneficial effects on endothelial function and insulin resistance in older men and women via hormonal (GH, IGF-I, IGFBP-3,-1, insulin) and non-hormonal actions...
Detailed Description
At the lower dose of 0.1 µg/kg/h, GHRP-3 presumably will improve endothelial dysfunction, enhance insulin action and lower blood pressure via the anti-inflammatory effects of GHRP-3 while at the highe...
Eligibility Criteria
Inclusion
- Men and post-menopausal women 50-70 years.
- Elevated fasting plasma glucose ranging \<125 mg/dL
- Waist circumference \>35 inches in women and \>40 inches in men
Exclusion
- Patients taking medications that may alter carbohydrate metabolism and/or insulin resistance.
- Female patients with a positive pregnancy test.
- Previous history of hypersensitivity to GHRP.
- Patients with overt liver disease, renal disease and/or congestive heart failure.
- Patients with anticipated change in medication regimen during the study period.
- Current use or history of use of hormone replacement therapy in the last six months.
- Current use or history of use of Ace Inhibitors or Angiotensin receptor blockers in the last six months.
- Hemoglobin of \< 11.6 g/dL for women and \< 12.9 g/dL for men.
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00846872
Start Date
July 1 2008
End Date
March 1 2012
Last Update
January 8 2021
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