Status:
COMPLETED
Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson's Disease
Depression
Eligibility:
All Genders
40+ years
Brief Summary
The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).
Eligibility Criteria
Inclusion
- Inclusion Criteria for STN-DBS subjects:
- Age 40 or older
- DBS STN Surgery in past 2 to 36 months
- Ability to tolerate turning off Stimulators
- Ability to read and comprehend questions
- English speaking
- Exclusion Criteria for STN-DBS subjects:
- Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
- Clinically determined Dementia ( Most recent MMSE score of \>24)
- Inclusion Criteria for Control subject:
- Age 40 or older
- Ability to read and comprehend questions
- English speaking
- Exclusion Criteria for Control subject:
- Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
- Clinically determined Dementia ( Most recent MMSE score of \>24)
- Plans to have DBS STN surgery in the next 24 months
Exclusion
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT00847431
Start Date
December 1 2008
End Date
December 1 2015
Last Update
May 4 2016
Active Locations (2)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
2
University of Cincinnati, Movement Disorder Center
Cincinnati, Ohio, United States, 45267-0525