Status:
COMPLETED
Endothelial Function in Human Arteries
Lead Sponsor:
The Cleveland Clinic
Conditions:
Endothelial Dysfunction
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Up to 30 patients with lower extremity disease scheduled to undergo diagnostic angiography will undergo baseline bloodwork and IVUS (intravascular ultrasound), followed by dosing with L-arginine to as...
Detailed Description
We will assess doses of regional L-arginine supplementation in patients undergoing elective angiography for lower extremity PAD. Assessment of EDR and EIR with IVUS in patent arteries will be performe...
Eligibility Criteria
Inclusion
- age \>18 years
- symptoms of intermittent claudication, rest pain or minor tissue loss (Rutherford Category I-V)
- ABI of \<.90
- angiographic demonstration of a 100mm patent segment of superficial femoral artery containing at least one distal runoff vessel
Exclusion
- acute limb ischemia,
- contraindication to angiography (creatinine \>2.5)
- concurrent oral anticoagulant therapy that cannot be safely withheld
- extensive tissue loss or gangrene
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00848302
Start Date
September 1 2009
End Date
January 1 2011
Last Update
March 7 2017
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