Status:
COMPLETED
Autologous Transplantation of Mesenchymal Stem Cells (MSCs) and Scaffold in Full-thickness Articular Cartilage
Lead Sponsor:
Royan Institute
Collaborating Sponsors:
Tehran University of Medical Sciences
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
45-60 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Bone Marrow Mesenchymal stem cells (MSCs) mixed with collagen I scaffold in patient with Knee carti...
Detailed Description
Articular cartilage defects have a weak potential for self-repair because of the reduced mitotic capacity of chondrocytes in vivo. Because some patients with articular cartilage defects may progress t...
Eligibility Criteria
Inclusion
- Age 45 to 60, inclusive
- Normal axial alignment
- Stable knee-previous ligament reconstruction, if stable
- Intact articular cartilage in posterior meniscal weight-bearing zone
- Ability to understand and willingness tosign consent from
- O.C.D or OA calgran classification II,III
Exclusion
- Pregnant or lactating
- Inflammatory arthritis
- Oral steriod, methotrexate
- Unable to follow post-operative exercise regimen or return for evaluations
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT00850187
Start Date
August 1 2008
End Date
December 1 2010
Last Update
January 5 2012
Active Locations (2)
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1
Royan Institute
Tehran, Tehran Province, Iran
2
Royan Institute
Tehran, Iran